| Product Name | TLCK |
|---|---|
| Description | TLCK is a trypsin-like serine protease inhibitor which can block lipopolysaccharide (LPS)- or cytokine-induced activation of nuclear factor κB (NF-κB), which, in turn blocks the induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) transcription. TLCK blocks activation of pp70s6k by all mitogens and prevents apoptosis in cell lines by inhibiting caspase processing. TLCK has been used in chymotrypsin purification to prevent binding of trypsins to the affinity support, as a protease inhibitor in tissue and cell homogenization and as a trypsin inhibitor to determine specific protease activity levels. |
| Synonyms | 4272-74-6, COX-2, PI-210, PI210, TLCK, caspase, cyclooxygenase-2 , lipopolysaccharide, serine protease |
| Molecular Weight | 369.31 Da |
| Target | Serine proteases,Other proteases |
| Amino Acid Sequence | (3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride |
| Form | Off white powder |
| Purity | >96% (TLC) |
| Cas Number | 4272-74-6 |
| Storage | Store desiccated, frozen and in the dark |
| References |
Kwon et al (1998) Evidence for involvement of the proteasome complex (26S) and NFkappaB in IL-1beta-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells. Diabetes 47(4) 583 PMID: 9568691Ménoret (2004) Purification of recombinant and endogenous HSP70s. Methods 32(1) 7 PMID: 14624870 Related areasAll small molecules >All serine protease modulators >All immunology research areas > |
| Supplier | Isca Biochemicals Limited |
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