| Product Name | TLQP 21 |
|---|---|
| Description |
TLQP 21 is a peptide named for its four N-terminal amino acids and length, which is derived from the 617 amino acid VGF precursor by proteolytic processing. The target for TLQP 21 is the C3a receptor-1 (C3aR1), a G-protein coupled receptor that is activated by the complement activation product C3a, itself considered a component of innate immunity. TLQP 21 plays a role in the central and peripheral nervous system to regulate feeding, reproductive and circadian behaviours and has a role in neuropathic pain and peripheral adiposity. |
| Synonyms | 869988-94-3, RT-020, RT020, TLQP 21, TLQP-21, TLQP21, TLQPPASSRRRHFHHALPPAR |
| Molecular Weight | 2432.77 Da |
| Target | Receptor tyrosine kinases |
| Amino Acid Sequence | TLQPPASSRRRHFHHALPPAR |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 869988-94-3 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Bartolomucci et al (2006) TLQP-21, a VGF-derived peptide, increases energy expenditure and prevents the early phase of diet-induced obesity. Proc Natl Acad Sci U S A. 103(39) 14584 PMID: 16983076Hannedouche (2013) Identification of the C3a receptor (C3AR1) as the target of the VGF-derived peptide TLQP-21 in rodent cells. J Biol Chem. 288(38) 27434 PMID: 23940034El Gaamouch et al (2020) VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice. Mol Neurodegeneration 15 4 https://doi.org/10.1186/s13024-020-0357-x Related areas All peptides >All receptor tyrosine kinase modulators >All immunology research categories >All neuroscience research categories > |
| Supplier | Isca Biochemicals Limited |
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