| Product Name | TLR2, 19-588aa, Human, Baculovirus |
|---|---|
| Description | TLR2, as known as toll-like receptor 2, belongs to the toll-like receptor (TLR) family. Human TLR family includes the members that activate the innate immune response via an ability to recognize molecular structures found in a variety of microbial pathogens. Specially, this protein is highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. It functions as part of a heterodimeric complex with either TLR1 or TLR6, and possibly other co-receptors. Recombinant human TLR2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Synonyms | Toll-like receptor 2 , TLR2, CD282, TIL4, CD282, CD282 antigen, TIL 4 TIL4, TLR 2, TLR2, TLR2_HUMAN, Toll like receptor 2 Toll like receptor 2 precursor, Toll-like receptor 2 Toll/interleukin 1 receptor like 4, Toll/interleukin 1 receptor like protein 4, Toll/interleukin receptor like protein 4, Toll/interleukin-1 receptor-like protein 4 |
| Host | Virus |
| Molecular Weight | 62.6kDa (543aa) confirmed by MALDI-TOF |
| Amino Acid Sequence | KEESSNQASL SCDRNGICKG SSGSLNSIPS GLTEAVKSLD LSNNRITYIS NSDLQRCVNL QALVLTSNGI NTIEEDSFSS LGSLEHLDLS YNYLSNLSSS WFKPLSSLTF LNLLGNPYKT LGETSLFSHL TKLQILRVGN MDTFTKIQRK DFAGLTFLEE LEIDASDLQS YEPKSLKSIQ NVSHLILHMK QHILLLEIFV DVTSSVECLE LRDTDLDTFH FSELSTGETN SLIKKFTFRN VKITDESLFQ VMKLLNQISG LLELEFDDCT LNGVGNFRAS DNDRVIDPGK VETLTIRRLH IPRFYLFYDL STLYSLTERV KRITVENSKV FLVPCLLSQH LKSLEYLDLS ENLMVEEYLK NSACEDAWPS LQTLILRQNH LASLEKTGET LLTLKNLTNI DISKNSFHSM PETCQWPEKM KYLNLSSTRI HSVTGCIPKT LEILDVSNNN LNLFSLNLPQ LKELYISRNK LMTLPDASLL PMLLVLKISR NAITTFSKEQ LDSFHTLKTL EAGGNNFICS CEFLSFTQEQ QALAKVLIDW PANYLCDSPS HVRGQQVQDV RLSVSECHRT LEHHHHHH |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-HCl (pH 8.0) containing 10% glycerol, 1mM DTT, 0.1M NaCl |
| Concentration | 1mg/ml (determined by Bradford assay) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Liu Y., et al. (2015) Eur. J. Immunol. 45:2683-2693. Murphy M., et al. (2015) J. Biol. Chem. 290:19218-19232. |
| Background | TLR2, as known as toll-like receptor 2, belongs to the toll-like receptor (TLR) family. Human TLR family includes the members that activate the innate immune response via an ability to recognize molecular structures found in a variety of microbial pathogens. Specially, this protein is highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. It functions as part of a heterodimeric complex with either TLR1 or TLR6, and possibly other co-receptors. Recombinant human TLR2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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