| Product Name | TPCK |
|---|---|
| Description | TPCK is an irreversible chymotrypsin-like serine protease inhibitor, acting as an alkylating agent that interferes with translation. TPCK is useful for inhibiting chymotrypsin activity in trypsin preparations. TPCK also inhibits apoptosis in thymocytes and blocks the induction of nitric oxide synthase by γ-interferon and lipopolysaccharides. |
| Synonyms | 402-71-1, PI-220, PI220, TPCK, apoptosis, chymotrypsin-like serine protease inhibitor |
| Molecular Weight | 351.85 Da |
| Target | Serine proteases |
| Amino Acid Sequence | N-p-Tosyl-L-phenylalanine chloromethyl ketone |
| Form | White solid |
| Purity | >98% by TLC |
| Cas Number | 402-71-1 |
| Storage | Store desiccated, frozen and in the dark |
| References |
Fearnhead et al (1995) A pre-existing protease is a common effector of thymocyte apoptosis mediated by diverse stimuli, FEBS Lett. 357 242 PMID: 7835420Griscavage et al (1996) Inhibitors of the Proteasome Pathway Interfere with Induction of Nitric Oxide Synthase in Macrophages by Blocking Activation of Transcription Factor NF-kappa. Proc. Natl. Acad. Sci. USA 93(8) 3308 PMID: 8622934 Related areas All small molecules >All serine protease modulators >All immunology research areas > |
| Supplier | Isca Biochemicals Limited |
All Research Products are sold for laboratory RESEARCH USE ONLY and ARE NOT TO BE USED FOR HUMAN OR ANIMAL THERAPEUTIC OR DIAGNOSTIC APPLICATIONS. The information presented is believed to be accurate; however, said information and products are offered without warranty or guarantee since the ultimate conditions of use and the variability of the materials treated are beyond our control. Nothing disclosed herein is to be construed as a recommendation to use our products in violation of any patents. ARP American Research Products, Inc. does not submit its products for regulatory review by any government body or other organization, and we do not validate them for clinical, therapeutic or diagnostic use, or for safety and effectiveness. You are solely responsible for making sure that the way you use the products complies with applicable laws, regulations and governmental policies and for obtaining all necessary approvals, intellectual property rights, licenses and permissions that you may need related to your use. Under no circumstances shall ARP American Research Products, Inc. be liable for damages, whether consequential, compensatory, incidental or special, strict liability or negligence, breach of warranty or any other theory arising out of the use of the products available from ARP American Research Products, Inc. Nothing contained herein warrants that the use of the products will not infringe on the claims of any patents covering the product itself or the use thereof in combination with other products or in the operation of any process. ARP American Research Products, Inc. disclaims any and all representations or warranties of any kind whatsoever, express or implied, including without limitation any implied warranties of merchantability or fitness for a particular purpose, of non-infringement, or regarding results obtained through the use of any product, whether arising from a statute or otherwise in law or from a course of performance, dealing or usage of trade.
