| Product Name | TRAF3 Monoclonal Antibody |
|---|---|
| Description | TNF receptor-associated factor 3 (TRAF3) has many alternative names including CAP-1,CD40 receptor-associated factor 1(CRAF1),CD40-binding protein(CD40BP) and LMP1-associated protein 1 (LAP1). TRAF3 regulates pathways leading to the activation of NF-kappa-B and MAP kinases,and plays a central role in the regulation of innate immune response. It modulates signaling pathways leading to the production of cytokines and interferon. As an essential constituent of several E3 ubiquitin-protein ligase complexes,TRAF3 promote 'Lys-63'-linked ubiquitination of target proteins. Moreover,TRAF3 undergoes both 'Lys-48'-linked and 'Lys-63'-linked ubiquitination in response to various stimuli and is deubiquitinated by OTUB1,OTUB2 and OTUD5. |
| Synonyms | CAP 1,CAP1,CD40 binding protein,CD40bp,CRAF1,LAP1,LMP1 associated protein 1,TRAF3 |
| Host | Mouse |
| Clone | 981 |
| Immunogen | Fusion protein of TRAF3 |
| Isotype | IgG2a |
| Reactivity | Human, Mouse |
| Applications | ELISA, IF, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | Q13114 |
| Background | TNF receptor-associated factor 3 (TRAF3) has many alternative names including CAP-1,CD40 receptor-associated factor 1(CRAF1),CD40-binding protein(CD40BP) and LMP1-associated protein 1 (LAP1). TRAF3 regulates pathways leading to the activation of NF-kappa-B and MAP kinases,and plays a central role in the regulation of innate immune response. It modulates signaling pathways leading to the production of cytokines and interferon. As an essential constituent of several E3 ubiquitin-protein ligase complexes,TRAF3 promote 'Lys-63'-linked ubiquitination of target proteins. Moreover,TRAF3 undergoes both 'Lys-48'-linked and 'Lys-63'-linked ubiquitination in response to various stimuli and is deubiquitinated by OTUB1,OTUB2 and OTUD5. |
| Supplier | Elabscience |
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