| Product Name | Transportan |
|---|---|
| Description |
Transportan is a 27 amino acid chimeric peptide consisting of 12 amino acids from the amino terminal of galanin and the 14 amino acid peptide mastoparan connected via a lysine residue. Transportan possesses characteristics of both galanin and mastoparan as it inhibits the binding of galanin to the GALR-1 receptor as well as modulating the activity of G proteins through inhibition of GTPase. Transportan is a cell-penetrating peptide which can penetrate into many cell types in a rapid and efficient way. In the cell interior, Transportan localizes mostly in membranous structures and is conveyed into the nuclei, where it concentrates in the nucleoli. |
| Synonyms | [Lys13]galparan |
| Molecular Weight | 2841.47 Da |
| Target | Galanin receptors |
| Amino Acid Sequence | GWTLNSAGYLLGKINLKALAALAKKIL |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: None |
| References |
Pooga et al (1998) Cell penetration by transportan. FASEB J. 12(1) 67 PMID: 9438412Pooga et al (2001), Cellular translocation of proteins by transportan. FASEB J. 5 1451 PMID: 11387254Aguiar etal (2019) Coupling the cell-penetrating peptides transportan and transportan 10 to primaquine enhances its activity against liver-stage malaria parasites. Med. Chem. Commun. 10 221 PMID: 30881610 Related areasAll cell penetrating peptides >All galanin receptor modulators > |
| Supplier | Isca Biochemicals Limited |
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