| Product Name | TRAP 6 amide |
|---|---|
| Description | TRAP 6 amide is the amidated version of TRAP 6, and both are a peptide fragment of protease-activated receptor 1 (PAR1, residues 42-47) that acts as a PAR1 agonist. TRAP 6 amide stimulates human platelet aggregation, promotes intracellular Ca2+ mobilization and induces rapid phosphodiesterase 3A (PDE3A) phosphorylation in vitro. |
| Synonyms | 141923-40-2, PR-090, SFLLRN-NH2, TRAP 6 amide |
| Molecular Weight | 747.89 Da |
| Target | Protease activated receptors |
| Amino Acid Sequence | SFLLRN-NH2 |
| Form | Freeze dreid solid |
| Purity | >95% by hplc |
| Cas Number | 141923-40-2 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C terminal amide |
| References |
Vassallo et al (1992) Structure-function relationships in the activation of platelet thrombin receptors by receptor derived peptides. J.Biol.Chem. 267 6081 PMID: 1313429Kaufmann et al (1999) PAR 1-type thrombin receptors are involved in thrombin-induced calcium signaling in human meningioma cells. J.Neurooncol. 42 131 PMID: 10421070Mitrugno et al (2018) Potentiation of TRAP-6-induced platelet dense granule release by blockade of P2Y12 signaling with MRS2395. Platelets 4 383 PMID: 28523947 Related data All peptides >All protease activated receptors >All cardiovascular research categories > |
| Supplier | Isca Biochemicals Limited |
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