| Product Name | TRIAP1 Antibody |
|---|---|
| Description | Rabbit polyclonal antibody to TRIAP1 |
| Synonyms | p53-inducible cell-survival factor antibody; p53CSV antibody; Protein 15E1.1 antibody; TP53-regulated inhibitor of apoptosis 1 antibody; TRIA1_HUMAN antibody; Triap1 antibody; WF 1 antibody; WF1 antibody |
| Host | Rabbit |
| Clonality | Polyclonal |
| Conjugate | Unconjugated |
| Immunogen | Recombinant human TP53-regulated inhibitor of apoptosis 1 protein (1-76AA) |
| Isotype | IgG |
| Target | TRIAP1 |
| Reactivity | Human |
| Applications | ELISA, IHC |
| Form | Liquid |
| Diluent Buffer | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Uniprot | O43715 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Background | Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003). |
| Supplier | Cusabio |
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