| Product Name | TRIB3, 1-358aa, Human (Denatured) |
|---|---|
| Description | TRIB3, also known as tribbles pseudokinase 3, is a putative protein kinase that is induced by the transcription factor NF-kappaB. This protein is a negative regulator of NF-kappaB, and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, it can negatively regulate the cell survival serine-threonine kinase AKT1. Recombinant human TRIB3 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
| Synonyms | Tribbles homolog 3, Tribbles homolog 3, C20orf97, NIPK, SINK, SKIP3, TRB3 |
| Host | E. coli |
| Molecular Weight | 15.1 kDa (134aa) |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMRATPLA APAGSLSRKK RLELDDNLDT ERPVQKRARS GPQPRLPPCL LPLSPPTAPD RATAVATASR LGPYVLLEPE EGGRAYQALH CPTGTEYTCK VYPVQEALAV LEPYARLPPH KHVARPTEVL AGTQLLYAFF TRTHGDMHSL VRSRHRIPEP EAAVLFRQMA TALAHCHQHG LVLRDLKLCR FVFADRERKK LVLENLEDSC VLTGPDDSLW DKHACPAYVG PEILSSRASY SGKAADVWSL GVALFTMLAG HYPFQDSEPV LLFGKIRRGA YALPAGLSAP ARCLVRCLLR REPAERLTAT GILLHPWLRQ DPMPLAPTRS HLWEAAQVVP DGLGLDEARE EEGDREVVLY G |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-HCl (pH8.0) containing 10% glycerol |
| Concentration | 0.25 mg/ml (determined by Bradford assay) |
| Purity | > 85% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Du K. et al. (2003) Science. 300:1574-1577. Hegedus Z. et al. (2006) Cell Mol Life Sci. 63:1632-1641. |
| Background | TRIB3, also known as tribbles pseudokinase 3, is a putative protein kinase that is induced by the transcription factor NF-kappaB. This protein is a negative regulator of NF-kappaB, and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, it can negatively regulate the cell survival serine-threonine kinase AKT1. Recombinant human TRIB3 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
| Supplier | ARP |
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