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|Product Name||TSC22D3, 1-134aa, Human|
|Amino Acid Sequence||MGSSHHHHHH SSGLVPRGSH MGSMNTEMYQ TPMEVAVYQL HNFSISFFSS LLGGDVVSVK LDNSASGASV VAIDNKIEQA MDLVKNHLMY AVREEVEILK EQIRELVEKN SQLERENTLL KTLASPEQLE KFQSCLSPEE PAPESPQVPE APGGSAV|
|Background||TSC22 domain family protein 3, also known as TSC22D3, protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, TSC22D3 plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, TSC22D3 inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities. Recombinant human TSC22D3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
|Concentration||0.5 mg/ml (determined by Bradford assay)|
|Form||Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol, 1mM DTT|
|Intended Use||For Research Use Only|
|Molecular Weight||25.3kDa (227aa) confirmed by MALDI-TOF
(Molecular size on SDS-PAGE will appear higher)
|NCBI Accession #||NP_004080|
|Purity||> 85% by SDS-PAGE|
|References||Asselin-Labat M.-L., et al. (2004) Blood. 104:215-223
Berrebi D., et al. (2003) Blood. 101:729-738
|Storage||Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.|
|Synonyms||TSC22 domain family protein 3, DIP, DSIPI, GILZ, hDIP, TSC-22R|
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