| Product Name | TULP1, 290-542aa, Human |
|---|---|
| Description | Tubby-related protein 1, also known as TULP1, is a member of the TULP family of four proteins (TUB and TULP1, -2, and -3), characterized structurally by the highly conserved C-terminal half of the protein. In the retina, TULP1 is found exclusively in photoreceptor cells, localizing primarily in the inner segments and connecting cilium and to a lesser extent in the perinuclear cytoplasm and synaptic termini. Recombinant human TULP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Synonyms | Tubby-related protein 1, LCA15, RP14, TUBL1 |
| Host | E. coli |
| Molecular Weight | 26.3 kDa (244aa), confirmed by MALDI-TOF |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSEPREFVL RPAPQGRTVR CRLTRDKKGM DRGMYPSYFL HLDTEKKVFL LAGRKRKRSK TANYLISIDP TNLSRGGENF IGKLRSNLLG NRFTVFDNGQ NPQRGYSTNV ASLRQELAAV IYETNVLGFR GPRRMTVIIP GMSAENERVP IRPRNASDGL LVRWQNKTLE SLIELHNKPP VWNDDSGSYT LNFQGRVTQA SVKNFQIVHA DDPDYIVLQF GRVAEDAFTL DYRYPLCALQ AFAIALSSFD GKLACE |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 20% glycerol,2mM DTT |
| Concentration | 0.25 mg/ml (determined by Bradford assay) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Xi Q., et al. (2005) Invest. Ophthalmol. Vis. Sci. 46:4754-4761 Caberoy N.B., et al. (2010) Exp. Cell Res. 316:245-257 |
| Background | Tubby-related protein 1, also known as TULP1, is a member of the TULP family of four proteins (TUB and TULP1, -2, and -3), characterized structurally by the highly conserved C-terminal half of the protein. In the retina, TULP1 is found exclusively in photoreceptor cells, localizing primarily in the inner segments and connecting cilium and to a lesser extent in the perinuclear cytoplasm and synaptic termini. Recombinant human TULP1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
| Supplier | ARP |
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