| Product Name | UBE2C Monoclonal Antibody |
|---|---|
| Description | UBE2C(Ubiquitin-conjugating enzyme E2 C) is also known as UBCH10 and belongs to the ubiquitin-conjugating enzyme family. It is highly expressed in a variety of human primary tumors,and it is able to promote cell proliferation and malignant transformation. UBE2C,along with the E3 ligase of the anaphasepromoting complex (APC),catalyzes the ubiquitination of mitotic cyclins A and B,as well as securin. UBE2C is essential for cell cycle progression,and mutation of its active site cysteine confers a dominant-negative phenotype. |
| Synonyms | dJ447F3.2,UBCH10,UBE2C,Ubiquitin carrier protein C,Ubiquitin protein ligase C |
| Host | Mouse |
| Clone | 230 |
| Immunogen | Fusion protein of UBE2C |
| Isotype | IgG1 |
| Reactivity | Human |
| Applications | ELISA, IF, IHC, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | O00762 |
| Background | UBE2C(Ubiquitin-conjugating enzyme E2 C) is also known as UBCH10 and belongs to the ubiquitin-conjugating enzyme family. It is highly expressed in a variety of human primary tumors,and it is able to promote cell proliferation and malignant transformation. UBE2C,along with the E3 ligase of the anaphasepromoting complex (APC),catalyzes the ubiquitination of mitotic cyclins A and B,as well as securin. UBE2C is essential for cell cycle progression,and mutation of its active site cysteine confers a dominant-negative phenotype. |
| Supplier | Elabscience |
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