| Product Name | UFP 101 |
|---|---|
| Description |
UFP 101 is a potent, selective and competitive antagonist at the nociceptin receptor. UFP 101 binds to nociceptin receptors with high affinity (pKi 10.24) and possesses ~3000 fold selectivity over the classical opioid receptors. UFP 101 is antinociceptive and opposes the action of nociceptin in vivo, with an antinociceptive effect when given i.c.v. while being inactive following spinal administration in mice. UFP 101 also shows antidepressant effects in distinct species and can reduce microvascular inflammation to lipopolysaccharide in vivo. |
| Synonyms | [Nphe1,Arg14,Lys15]nociceptin-NH2, [Nphe1, Arg14, Lys15] N/OFQ€NH2 |
| Molecular Weight | 1908.19 Da |
| Target | Nociceptin receptors |
| Amino Acid Sequence | Bn-GGGFTGARKSARKRKNQ-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 849024-68-6 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: N-terminal benzyl, C-terminal amide |
| References |
Calo et al (2002) [Nphe1,Arg14,Lys15]Nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor. Br.J.Pharmacol. 136 303 PMID: 12010780Calo et al (2005) UFP-101, a peptide antagonist selective for the nociceptin/orphanin FQ receptor. CNS Drug Rev. 11(2) 97 PMID: 16007234Brookes et al (2013) The nociceptin/orphanin FQ receptor antagonist UFP-101 reduces microvascular inflammation to lipopolysaccharide in vivo. PLoS One 8(9) e74943 PMID: 24086402 Related areas All peptides >All nociceptin receptor modulators >All pain research categories >All neuroscience research categories > |
| Supplier | Isca Biochemicals Limited |
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