USP30 Antibody

Category: Antibodies
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CSB-PA765106LA01HU
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Product Name USP30 Antibody
Description Rabbit polyclonal antibody to USP30
Synonyms Deubiquitinating enzyme 30 antibody; FLJ40511 antibody; Ub-specific protease 30 antibody; Ubiquitin carboxyl terminal hydrolase 30 antibody; Ubiquitin carboxyl-terminal hydrolase 30 antibody; Ubiquitin specific peptidase 30 antibody; Ubiquitin specific processing protease 30 antibody; Ubiquitin thioesterase 30 antibody; Ubiquitin thiolesterase 30 antibody; Ubiquitin-specific-processing protease 30 antibody; UBP30_HUMAN antibody; usp30 antibody
Host Rabbit
Clonality Polyclonal
Conjugate Unconjugated
Immunogen Recombinant human Ubiquitin carboxyl-terminal hydrolase 30 protein (101-400AA)
Isotype IgG
Target USP30
Reactivity Human
Applications ELISA, IHC
Form Liquid
Diluent Buffer Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Uniprot Q70CQ3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Background Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PARK2): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).
Supplier Cusabio

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