Product Name | USP37 Antibody |
---|---|
Description | Rabbit polyclonal antibody to USP37 |
Synonyms | Deubiquitinating enzyme 3 antibody; Deubiquitinating enzyme 37 antibody; EC 3.1.2.15 antibody; KIAA1594 antibody; MGC117261 antibody; OTTHUMP00000164146 antibody; tmp_locus_50 antibody; Ubiquitin carboxyl-terminal hydrolase 37 antibody; Ubiquitin specific peptidase 37 antibody; Ubiquitin specific processing protease 37 antibody; Ubiquitin specific protease 37 antibody; Ubiquitin thioesterase 37 antibody; Ubiquitin thiolesterase 37 antibody; Ubiquitin-specific-processing protease 37 antibody; UBP37_HUMAN antibody; USP37 antibody |
Host | Rabbit |
Clonality | Polyclonal |
Conjugate | Unconjugated |
Immunogen | Recombinant Human Ubiquitin carboxyl-terminal hydrolase 37 protein (671-797AA) |
Isotype | IgG |
Target | USP37 |
Reactivity | Human |
Applications | ELISA, IHC |
Form | Liquid |
Diluent Buffer | Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Uniprot | Q86T82 |
Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
Background | Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). |
Supplier | Cusabio |
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