| Product Name | USP5 Monoclonal Antibody |
|---|---|
| Description | USP5,also named as ISOT,belongs to the peptidase C19 family. Knock-down of USP5 causes the accumulation of TP53/p53 and an increase in TP53/p53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated TP53/p53 but not with MDM2 for proteasomal recognition. USP5 is a potential target for p53 activating therapeutic agents for the treatment of cancer. It is a novel proteasome associated protein. USP5 cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. |
| Synonyms | Deubiquitinating enzyme 5,Isopeptidase T,ISOT,Ubiquitin thiolesterase 5,USP5 |
| Host | Mouse |
| Clone | 356 |
| Immunogen | Fusion protein of USP5 |
| Isotype | IgG2a |
| Reactivity | Human |
| Applications | ELISA, WB |
| Form | PBS with 0.02% sodium azide, 50% glycerol, PH7.3 |
| Uniprot | P45974 |
| Background | USP5,also named as ISOT,belongs to the peptidase C19 family. Knock-down of USP5 causes the accumulation of TP53/p53 and an increase in TP53/p53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated TP53/p53 but not with MDM2 for proteasomal recognition. USP5 is a potential target for p53 activating therapeutic agents for the treatment of cancer. It is a novel proteasome associated protein. USP5 cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. |
| Supplier | Elabscience |
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