| Product Name | VAMP4, 1-115aa, Human, Recombinant |
|---|---|
| Description | VAMP4, also known as vesicle-associated membrane protein 4, is a member of the synaptobrevin family involved in docking and/or fusion of vesicles with cell membrane. This protein is enriched in the trans-Golgi network and may play a role in trans-Golgi network-to-endosome transport. VAMP4 is involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. Recombinant human VAMP4 protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography. |
| Synonyms | VAMP24, Vesicle-associated membrane protein 4 VAMP 24, VAMP 4, VAMP4 protein, Vesicle associated membrane protein 4, Vesicle associated membrane protein 4, isoform CRA a, Vesicle associated membrane protein 4, isoform CRA b. |
| Host | E. coli |
| Molecular Weight | 46.8 kDa (437aa), confirmed by MALDI-TOF. |
| Amino Acid Sequence | MPPKFKRHLN DDDVTGSVKS ERRNLLEDDS DEEEDFFLRG PSGPRFGPRN DKIKHVQNQV DEVIDVMQEN ITKVIERGER LDELQDKSES LSDNATAFSN RSKQLRRQMW WRGCKLEHHH HHH |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20 mM Tris (pH 8.0) , containing 10% Glycerol, 1mM DTT. |
| Concentration | 1 mg/ml (determined by Bradford assay) |
| Purity | > 90% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Tran TH., et al. (2007) J Cell Sci. 120:1028-41. Steegmaier M., et al. (1999) Mol Biol Cell. 10(6):1957-72. |
| Background | VAMP4, also known as vesicle-associated membrane protein 4, is a member of the synaptobrevin family involved in docking and/or fusion of vesicles with cell membrane. This protein is enriched in the trans-Golgi network and may play a role in trans-Golgi network-to-endosome transport. VAMP4 is involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. Recombinant human VAMP4 protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography. |
| Supplier | ARP |
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