| Product Name | Vascular Endothelial Growth Factor-165, VEGF-165, RAT |
|---|---|
| Description | Vascular Endothelial Growth Factor-A (VEGF-A) was originally isolated from tumor cells and is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability, VEGF-A may play a role in stimulating vasodilatation via nitric oxide-dependent pathways. VEGF-A has several variants, VEGF-165 being the most abundant. Rat and bovine VEGF are one amino acid shorter than the human factor, and the bovine and human sequences show a homology of 95%. |
| Synonyms | VEGF-A, VPF, glioma-derived endothelial cell mitogen |
| Molecular Weight | Recombinant rat VEGF-165 is a disulfide linked homodimer, containing two 165 amino acids chains, with a total molecular weight of 38.8 kDa. |
| Amino Acid Sequence | MAPTTEGEQK AHEVVKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNVTMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKHCEPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR |
| Biological Activity | The activity is determined by the dose-dependent induced proliferation of Human umbilical vein endothelial cells (HUVECs) and is typically 4.0-8.0 ng/mL. |
| Reactivity | Rat |
| Form | Purified, sterile filter |
| Purity | 0.97 |
| Storage | 2-8C for short term. Aliquot and store at -2°C for long term. Avoid repeated freezing and thawing cycles. |
| Supplier | ARP |
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