| Product Name | VPM-p15 |
|---|---|
| Description |
VPM-p15 is an optimised version of the peptide p15, itself an activator derived from the ADGRG2 Stachel sequence, an agonist sequence found within within the large ectodomains of members of the adhesion G protein-coupled receptor (aGPCR) family. VPM-p15 activates ADGRG2 with significantly improved (>2 orders of magnitude) affinity compared to p15. VPM-p15 is a useful tool to investigate the function of ADGRG2, which is a critical regulator of male fertility that maintains ion/pH homeostasis and CFTR coupling. |
| Synonyms | T1V/F3Phe(4-Me) |
| Molecular Weight | 1631.91 Da |
| Target | Orphan 7-TM receptors |
| Amino Acid Sequence | VSXGILLDLSRTSLP |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: X is 4-methylphenylalanine |
| References |
Sun et al (2021) Optimization of a peptide ligand for the adhesion GPCR ADGRG2 provides a potent tool to explore receptor biology. J Biol Chem. 296 100174 PMID: 33303626 Related areasAll peptides >All adhesion class receptors >All endocrinology categories > |
| Supplier | Isca Biochemicals Limited |
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