| Product Name | WKYMVm |
|---|---|
| Description |
WKYMVm is a selective agonist for formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM) when expressed on immune cells. WKYMVm induces Ca2+ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. WKYMVm has pleiotropic anti-inflammatory, pro-angiogenic, anti-apoptotic and immunomodulatory effects in various animal models of sepsis, ulcerative colitis, myocardial infarction, ischemic hindlimb and diabetic cutaneous wound healing. |
| Synonyms | Leukocyte chemoattractant peptide |
| Molecular Weight | 856.11 Da |
| Target | Formyl peptide receptors |
| Amino Acid Sequence | WKYMVm-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 187986-17-0 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: Methionine 6 is D-Met, C-terminal amide |
| References |
Christophe et al (2001) The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J.Biol.Chem. 276 21585 PMID: 11285256Shin (2005) The Synthetic Chemoattractant Peptide WKYMVm Induces Superoxide Production by Human Eosinophils via the Phosphoinositide 3-Kinase-Mediated Activation of ERK1/2. Int Arch Allergy Immunol. 137(suppl 1) 21 PMID: 15947481Kim et al (2019) WKYMVm hexapeptide, a strong formyl peptide receptor 2 agonist, attenuates hyperoxia-induced lung injuries in newborn mice. Sci Rep 9 6815 PMID: 31048743 Related areasAll peptides >All formyl peptide receptor modulators >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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