| Product Name | WKYMVM |
|---|---|
| Description |
WKYMVM is a potent N-formyl peptide receptor agonist. WKYMVM activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. WKYMVM also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and can activate NADPH oxidase |
| Synonyms | W-peptide |
| Molecular Weight | 856.11 Da |
| Target | Formyl peptide receptors |
| Amino Acid Sequence | WKYMVM-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 187986-11-4 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C-terminal amide |
| References |
Christophe et al (2001) The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J.Biol.Chem. 276 21585 PMID: 11285256Christophe et al (2002) Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1 /LXA4R, is not affected by lipoxin. Scand.J.Immunol. 56 470 PMID: 12410796Karlsson et al (2007) Ability of monocyte-derived dendritic cells to secrete oxygen radicals in response to formyl peptide receptor family agonists compared to that of myeloid and plasmacytoid dendritic cells. Clin Vaccine Immunol. 14(3) 328 PMID: 17215332 Related areas All peptides >All formyl peptide receptor modulators >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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