| Product Name | WRW4 |
|---|---|
| Description | WRW4 is a selective antagonist of formyl peptide receptor 2 (FPR2) signaling, which can inhibit WKYMVm binding to FPR2 with an C50 of 0.23 μM and can also inhibit intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. WRW4 inhibits FPR2-mediated signaling in human neutrophils and blocks chemotactic migration and superoxide generation by amyloid β42 peptide. WRW4 can reduce Brucella proliferation in animal models. |
| Synonyms | 878557-55-2, FR-020 , WRW4, WRWWWW-NH2 |
| Molecular Weight | 1104.28 Da |
| Target | Formyl peptide receptors |
| Amino Acid Sequence | WRWWWW-NH2 |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 878557-55-2 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: C-terminal amide |
| References |
Bae et al (2004) Identification of peptides that antagonize formyl peptide receptor-like 1-mediating signaling. J.Immunol. 173 607 PMID: 15210823Kain et al (2018), Inhibition of FPR2 Impaired Leukocyte Get€in Signal and Triggers Non€Resolving Inflammation in Heart Failure. FASEB J. 32 287 PMID: 31216426Reyes et al (2021) Formyl peptide receptor 2 (FPR2) antagonism is a potential target for the prevention of Brucella abortus 544 infection, Immunobiology 226(3) 152073 https://doi.org/10.1016/j.imbio.2021.152073 Related areas All peptides >All formyl peptide receptor modulators >All immunology research categories > |
| Supplier | Isca Biochemicals Limited |
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