| Product Name | Z-DEVD-FMK |
|---|---|
| Description |
Z-DEVD-FMK is a cell-permeable, irreversible inhibitor of caspase-3 with an IC50 of 0.13 µM and no activity at cathepsin B and cathepsin L. Z-DEVD-FMK inhibits apoptotic cell death in many cell types including cancer cells, it is neuroprotective in rat hippocampus following seizures in vivo and local application of Z-DEVD-FMK after spinal cord injury in rats reduces secondary tissue injury and helps preserve motor function. |
| Synonyms | Z-DEVD-fluoromethyl ketone, z-DEVD.fmk |
| Molecular Weight | 668.67 Da |
| Target | Caspases |
| Amino Acid Sequence | DEVD |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 210344-95-9 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: Asp-1 = Z-Asp(OMe), Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone |
| References |
Ma et al (1998) Synergistic effects of caspase inhibitors and MK-801 in brain injury after transient focal cerebral ischaemia in mice. Br J Pharmacol. 124(4) 756 PMID: 9690868Henshall et al (2000) Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. J.Neurochem. 74 1215 PMID: 10693954Barut et al (2005) The neuroprotective effects of z-DEVD.fmk, a caspase-3 inhibitor, on traumatic spinal cord injury in rats. Surg Neurol. 64(3) 213 PMID: 16099247 Related areas All peptides >All caspase modulators >All neuroscience research categories > |
| Supplier | Isca Biochemicals Limited |
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