| Product Name | Z-VAD-FMK |
|---|---|
| Description | Z-VAD-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable, irreversible pan-caspase inhibitor. Z-VAD-FMK inhibits caspase processing and apoptosis induction in tumour cells in vitro with an IC50 of 0.0015 - 5.8 mM). Z-VAD-FMK is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability. Z-VAD-FMK is active in vivo and can inhibit apoptosis in numerous settings. |
| Synonyms | Z-Val-Ala-Asp(OMe)-FMK |
| Molecular Weight | 467.49 Da |
| Target | Caspases |
| Amino Acid Sequence | Z-VAD-FMK |
| Form | White lyophilised solid |
| Purity | >98% by TLC |
| Cas Number | 187389-52-2 |
| Storage | Store dry, dark and frozen |
| Notes | Modifications: Benzyloxycarbonyl (Z) at N terminal, Fluoromethylketone (FMK) at C terminal |
| References |
Slee et al (1996) Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem.J. 315 21 PMID: 8670109Ilangovan et al (2003) Inhibition of apoptosis by Z-VAD-fmk in SMN-depleted S2 cells. J. Biol. Chem. 278(33) 30993 PMID: 12783893Simmons et al (2009) Pretreatment with pancaspase inhibitor (Z-VAD-FMK) delays but does not prevent intraperitoneal heat-killed group B Streptococcus-induced preterm delivery in a pregnant mouse model. Infect. Dis. Obstet. Gynecol. 2009 749432 PMID: 20069051 Related areas All peptides >All caspase modulators >All cancer research categories > |
| Supplier | Isca Biochemicals Limited |
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