| Product Name | ZCCHC12, 1-402aa, Human |
|---|---|
| Description | ZCCHC12 belongs to the ZCCHC12 family and contains 1 CCHC-type zinc finger. This protein is a transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression. Recombinant human ZCCHC12 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
| Synonyms | Znc finger CCHC domain-containing protein 12, PNMA7A, SIZN, SIZN1 |
| Host | E. coli |
| Molecular Weight | 36.6 kDa (334aa) confirmed by MALDI-TOF |
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMASIIAR VGNSRRLNAP LPPWAHSMLR SLGRSLGPIM ASMADRNMKL FSGRVVPAQG EETFENWLTQ VNGVLPDWNM SEEEKLKRLM KTLRGPAREV MRVLQATNPN LSVADFLRAM KLVFGESESS VTAHGKFFNT LQAQGEKASL YVIRLEVQLQ NAIQAGIIAE KDANRTRLQQ LLLGGELSRD LRLRLKDFLR MYANEQERLP NFLELIRMVR EEEDWDDAFI KRKRPKRSES MVERAVSPVA FQGSPPIVIG SADCNVIEID DTLDDSDEDV ILVESQDPPL PSWGAPPLRD RARPQDEVLV IDSPHNSRAQ FPSTSGGSGY KNNGPGEMRR ARKRKHTIRC SYCGEEGHSK ETCDNESDKA QVFENLIITL QELTHTEMER SRVAPGEYND FSEPL |
| Tag | His-tag |
| Reactivity | Human |
| Applications | SDS-PAGE |
| Form | Liquid, in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol |
| Concentration | 0.25 mg/ml (determined by Bradford assay) |
| Purity | > 85% by SDS-PAGE |
| Storage | Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -2°C or -7°C. Avoid repeated freezing and thawing cycles. |
| References | Li,Q.L, et al. (2012) Med. Oncol. 29 (3), 1409-1417 Cho,G., et al. (2009) J. Biol. Chem. 284 (29), 19592-19600 |
| Background | ZCCHC12 belongs to the ZCCHC12 family and contains 1 CCHC-type zinc finger. This protein is a transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression. Recombinant human ZCCHC12 protein, fused to His-tag at N-terminus, was expressed in E.coli. |
| Supplier | ARP |
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