| Product Name | ZIP |
|---|---|
| Description |
ZIP, or Zeta inhibitory peptide, is a cell permeable pseudo-substrate inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. ZIP selectively blocks PKMζ induced synaptic potentiation in hippocampal slices in vitro and is widely used to investigate memory in a variety of learning tasks, including spatial sensitization, pain sensitization, fear-associated memories, conditioned taste aversion and development of locomotor sensitization in rodents. However, LTP and LTM are unaffected in both constitutive and conditional PKMζ knock-out mice, yet both are still impaired by ZIP application, suggesting another mechanism of action which may involve ionotropic glutamate AMPA receptors (AMPARs). |
| Synonyms | z-Pseudosubstrate inhibitory peptide, Zeta inhibitory peptide, PKCζ (113-125), myristoylated |
| Molecular Weight | 1928.4 Da |
| Target | Kinases |
| Amino Acid Sequence | Myr-SIYRRGARRWRKL |
| Form | Freeze dried solid |
| Purity | >95% by hplc |
| Cas Number | 863987-12-6 |
| Storage | Store dry, frozen and in the dark |
| Notes | Modifications: N terminal myristoyl |
| References |
Serrano et al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979 PMID: 15728837LeBlancq et al (2016) ZIP It: Neural Silencing Is an Additional Effect of the PKM-Zeta Inhibitor Zeta-Inhibitory Peptide. J. Neuroscience 36 (23) 6193 DOI: 10.1523/JNEUROSCI.4563-14.2016Bingor et al (2020) Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors. Nat Commun 11 3688 https://doi.org/10.1038/s41467-020-17484-y Related areasAll peptides >All kinase modulators >All neuroscience categories > |
| Supplier | Isca Biochemicals Limited |
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